BCL-2 inhibits apoptosis, and its overexpression and phosphorylation participate in the regulation of cell proliferation, playing an extremely important role in tumor formation and multidrug resistance. The study found (117) that mRNA and protein levels of BCL-2 were upregulated in HCC tissues.

bcl2가 세포분열을 억제하면서 그 과정에서 유전자 결함이 생기는 식으로도 암이 발생한다.