https://www.biorxiv.org/content/10.1101/2024.02.10.579753v2.full#

Androgens at the skin surface regulate S. aureus pathogenesis through the activation of agr quorum sensingStaphylococcus aureus, the most frequent cause of skin infections, is more common in men than women and selectively colonizes the skin during inflammation. Yet, the specific cues that drive infection in these settings remain unclear. Here we show that the host androgens testosterone and dihydrotestosterone promote S. aureus pathogenesis and skin infection. Without the secretion of these hormones, skin infection in vivo is limited. Testosterone activates S. aureus virulence in a concentration dependent manner through stimulation of the agr quorum sensing system, with the capacity to circumvent other inhibitory signals in the environment. Taken together, our work defines a previously uncharacterized inter-kingdom signal between the skin and the opportunistic pathogen S. aureus and identifies the mechanism of sex-dependent differences in S. aureus skin infection.One-Sentence Summary Testosterone promotes S. aureus pathogenesis through activation of the agr quorum sensing system.### Competing Interest StatementThe authors have declared no competing interest.www.biorxiv.org


주요 안드로겐(남성호르몬)인 테스토스테론과 디하이드로테스토스테론(dht)는

대다수 피부 감염의 주 원인인 황색포도상구균의 독성을 활성화하고, 신체의 억제 신호를 우회하여 피부 미생물군집을 황색포도상구균이 유리한 환경으로 바꿉니다